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SGD SERAIL development of the first UNIFLUID TM refrigeration system System GMP: Locking system associated one double hinge and dual gaskets devices Validated CIP system with 180%  mechancally driven rotating spraying system First trayless: fully automatic Loading and Unloading system (Batch loader) Shelf Loading system connected to one 60m2 Freeze-Dryer : This system working at 100 vials/minute SERAIL presents his new PC / PLC systems associating one PC supervisor to a reliable PLC Central UNIFLUID TM  loop management connected to 3 Freeze-Dryers SERAIL develops range of cascade refrigeration using single stage reciprocating compressors to fully comply to the Montreal protocol using only HFC's  First Isolated Automatic Shelf Loading/Unloading system In order to improve maintenance system aspects, SERAIL develops cascading systems with single stage screw compressors 21 CFR11 part control system using SQL server High speed automatic Loading/Unloading Isolated pushing system on loading side and shelf by shelf shuttle unloading side. Automatic Isolated Loading system working at 1000 vials / minutes. GAMP IV documentation improvement Validation of the technology of CRYOPUMP validation based on control transfer mass to the condenser during the sublimation